Enomoto Y, Katsura H, Fujimura T, Ogata A, Baba S, Yamaoka A, Kihara M, Abe T, Nishimura O, Kadota M, Hazama D, Tanaka Y, Maniwa Y, Nagano T, Morimoto M.
Autocrine TGF-β-positive feedback in profibrotic AT2-lineage cells plays a crucial role in non-inflammatory lung fibrogenesis
Nature Communications 14, Article number: 4956 (2023)
[Nature Communications] [理研ニュース]

Fujimura T, Enomoto Y, Katsura H, Ogawa T, Baba S,, Ogata A, Yamaoka A, Shiroguchi K, Morimoto M.
Identifying a Lung Stem Cell Subpopulation by Combining Single-Cell Morphometrics, Organoid Culture, and Transcriptomics
Stem Cells 41(8)(2023)
[Stem Cells] [理研ニュース]

Kishimoto K, Iwasawa K, Sorel A, Ferran-Heredia C, Han L, Morimoto M, Wells JM, Takebe T, Zorn AM*.
Mammalian tracheal development and reconstruction: insights from in vivo and in vitro studies.
Nature Protocols 17(11) (2022)
[Nature Protocols] [理研ニュース]

Kishimoto K and Morimoto M*.
Mammalian tracheal development and reconstruction: insights from in vivo and in vitro studies.
Development 148: 13 (2021)
[PubMed] [Development]

Kiyokawa H and Morimoto M*.
Molecular crosstalk in tracheal development and its recurrence in adult tissue regeneration.
Developmental Dynamics (2021)
[PubMed] [Dev. Dyn.]

Kiyokawa H, Yamaoka A, Matsuoka C, Tokuhara T, Abe T, Morimoto M*.
Airway basal stem cells reutilize the embryonicproliferation regulator, Tgfb-Id2 axis, for tissue regeneration.
Developmental Cell vol. 56 (2021)
[Dev. Cell]

Kishimoto K, Furukawa KT, Luz-Madrigal A, Yamaoka A, Matsuoka C, Habu M, Alev C, Zorn AM, Morimoto M*.
Bidirectional Wnt signaling between endoderm and mesoderm confers tracheal identity in mouse and human cells.
Nature Communications vol. 11: 4159 (2020)
[PubMed] [Nat. Comm.] [理研ニュース]

Han L#, Chaturvedi P#, Kishimoto K#, Koike H, Nasr T, Iwasawa K, Giesbrecht K, Witcher PC, Eicher A, Haines L, Lee Y, Shannon JM, Morimoto M, Wells JM, Takebe T, Zorn AM*. (#Equally contributed)
Single cell transcriptomics identifies a signaling network coordinating endoderm and mesoderm diversification during foregut organogenesis.
Nature Communications vol. 11: 4158 (2020)
[PubMed] [Nat. Comm.]

Kiyokawa H, Morimoto M*.
Notch signaling in the mammalian respiratory system, specifically the trachea and lungs, in development, homeostasis, regeneration, and disease.
Dev. Growth Differ. (2019)
[PubMed]  [Dev. Growth Differ.]

Kishimoto K, Tamura M, Nishita M, Minami Y, Yamaoka A, Abe T, Shigeta M, Morimoto M*.
Synchronized mesenchymal cell polarization and differentiation shape the formation of the murine trachea and esophagus.
Nature Communications vol. 9: 2816 (2018)
[PubMed] [Nat. Comm.]

Yin W, Kim HT, Wang SP, Gunawan F, Wang L, Kishimoto K, Zhong H, Roman D, Preussner J, Guenther S, Graef V, Buettner C, Grohmann B, Looso B, Morimoto M, Mardon G, Offermanns S, Stainier DYR*.
The potassium channel KCNJ13 is essential for smooth muscle cytoskeletal organization during mouse tracheal tubulogenesis.
Nature Communications vol. 9: 2815 (2018)
[PubMed] [Nat. Comm.]

Tsukiji N, Inoue O, Morimoto M, Tatsumi N, Nagatomo H, Ueta K, Shirai T, Sasaki T, Otake S, Tamura S, Tachibana T, Okabe M, Hirashima M, Ozaki Y, Suzuki-Inoue K*
Platelets play an essential role in murine lung development through Clec-2/podoplanin interaction.
Blood (2018)
[PubMed] [Blood]

Tsao P, Matsuoka C, Wei SC, Sato A, Sato S, Chena HK, Ling TY, Mori M, Cardoso WV, Morimoto M*
Epithelial Notch signaling regulates lung alveolar morphogenesis and airway epithelial integrity.
Proc. Natl. Acad. Sci. USA 113, 8242-7 (2016)
[PubMed] [PNAS] [CDB News]

Noguchi M, Sumiyama K, Morimoto M*
Directed migration of pulmonary neuroendocrine cells toward airway branches organizes the stereotypic location of neuroepithelial bodies.
Cell Reports 13. - (2015)
[PubMed] [Cell Reports]

Liu Z, Brunskill E, Varnum-Finney B, Zhang C, Zhang A, Jay PY, Bernstein I, Morimoto M, Kopan R.
The intracellular domains of Notch1 and Notch2 are functionally equivalent during development and carcinogenesis.
Development 142, 2451-63 (2015)
[PubMed] [Development]

Okazawa M, Murashima A, Harada M, Nakagata N, Noguchi M, Morimoto M, Kimura T, Ornitz DM, Yamada G*
Region-specific regulation of cell proliferation by FGF receptor signaling during the Wolffian duct development.
Developmental Biology 400. 139-47 (2015)
[PubMed] [Developmental Biology]

The FANTOM consortium
Transcribed enhancers lead waves of coordinated transcription in transitioning mammalian cells.
Science 347.1010-1014 (2015)
[PubMed] [Science]

The FANTOM consortium
A promoter-level mammalian expression atlas.
Nature 507.462-470 (2014)
*involved in a transcriptional analysis of tracheal ciliated cells
[PubMed] [Nature] 

Morimoto M*, Nishinakamura R, Saga Y, Kopan R.
Different assemblies of Notch receptors coordinate the distribution of the major bronchial Clara, ciliated and neuroendocrine cells.
Development 139.4365-73 (2012)
[PubMed] [Development] [pdf]

Morimoto M, Liu Z, Cheng HT, Winters N, Bader D, Kopan R*.
Canonical Notch signaling in the developing lung is required for determination of arterial smooth muscle cells and selection of Clara versus ciliated cell fate.
J Cell Sci 123.213-24 (2010)
[PubMed] [J Cell Sci] [pdf]

Demehri S, Morimoto M, Holtzman MJ, and Kopan R*.
Skin-derived TSLP triggers progression from epidermal-barrier defects to asthma.
PLoS Biol 7(5).e1000067 (2009)
[PubMed] [PLoS Biol] [pdf]

Morimoto M and Kopan R*.
rtTA toxicity limits the usefulness of the SP-C-rtTA transgenic mouse.
Developmental Biology 325.171-8 (2009)
[PubMed] [Dev Biol] [pdf]

Morimoto M, Sasaki N, Oginuma M, Kiso M, Igarashi K, Aizaki K, Kanno J, Saga Y*.
The negative regulation of Mesp2 by mouse Ripply2 is required to establish the rostro-caudal patterning within a somite.
Development 134.1561-9 (2007)
[PubMed] [Development] [pdf]

Morimoto M, Kiso M, Sasaki N, Saga Y*.
Cooperative Mesp activity is required for normal somitogenesis along the anterior-posterior axis.
Developmental Biology 300.687-98 (2006)
[PubMed] [Dev Biol] [pdf]

Nakajima Y, Morimoto M, Takahashi Y, Koseki H, Saga Y*.
Identification of Epha4 enhancer required for segmental expression and the regulation by Mesp2.
Development 133.2517-25 (2006)
[PubMed] [Development] [pdf]

Morimoto M,Takahashi Y, Endo M, Saga Y*.
The Mesp2 transcription factor establishes segmental borders by suppressing Notch activity.
Nature 435.354-9 (2005)
[PubMed] [Nature] [pdf]

Morimoto M, Nishida T, Nagayama Y, Yasuda H*.
Nedd8-modification of Cul1 is promoted by Roc1 as a Nedd8-E3 ligase and regulates its stability.
Biochem Biophys Res Commun 301.392-8 (2003)
[PubMed] [Biochem Biophys Res Commun] [pdf]

Morimoto M, Nishida T, Honda R, Yasuda H*.
Modification of cullin-1 by ubiquitin-like protein Nedd8 enhances the activity of SCF(skp2) toward p27(kip1).
Biochem Biophys Res Commun 270.1093-6 (2000)
[PubMed] [Biochem Biophys Res Commun] [pdf]

森本 充

Mitsuru Morimoto
 Building Functional Internal Organs from a Naive Endodermal Sheet
 [New Principles in Developmental Processes], Part I-5, Springer社(2014)

森本 充

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